Traffic is at a standstill on the eastbound carriageway between junction 21 for Milnrow and Shaw and junction 22 for Saddleworth near Rochdale. Highways England said they were dealing with a road traffic collision.
The lorry was travelling eastbound along the M62 and overturned across the hard shoulder and Lane One.
As well as this, a car collided with the central reservation and came stationary in Lane Four of the eastbound carriageway.
Highways England said the incidents are causing large spillages of diesel to spread across the carriageway.
Traffic officers are currently on the scene with specialist recovery agents.
In a tweet, they said: “Highways England are dealing with an RTC on the #M62 EB between J21 & J22.
“All traffic currently stopped whilst some of the vehicles are moved to a safer location.”
The motorway closure is due to be closed throughout the morning because of a complex recovery process.
Highways England continued on Twitter: “We’re in the process of organising extra resources to assist in turning around any vehicles stuck inside the closure.”
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