The Duke of Sussex and talkshow legend had previously planned to release a series together on the subject of mental health. Speculation over the TV project has been circulating for two years.
But the project is believed to have been delayed with vague plans for when it is due to be released.
The show was expected to stream on Apple TV in Autumn 2020.
However, the series is now not expected to begin filming until later this year according to reports.
An insider told the Sun that updates on the show have been kept under wraps because “delays never look good”.
In 2019, Sussex Royal announced on social media that Prince Harry and Ms Winfrey would be starring together in a “mental health series”.
Prince Harry was said to be a “co-creator and executive producer” on the series.
A Sussex Royal Instagram post read: “We are excited to announce The Duke of Sussex and Oprah Winfrey are partners, co-creators and executive producers on their forthcoming mental health series launching on Apple in 2020.”
Since then the Duke and Duchess of Sussex decided to step down as senior members of the Royal Family.
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The first episode marked the start of their Archewell Audio project.
The Duchess told listeners: “No matter what life throws at you guys, trust us when we say, love wins.”
During the episode, the couple chose not to discuss their own experiences of 2020 but instead decided to invite the celebrities who they “admire, and get their thoughts on what they learned from 2020″.
Last year, the Sussexes announced they would be teaming up with Netflix to create shows for the platform.
The couple said they want to focus on content “that informs but also gives hope”.
As parents to a one-year old, the couple also plans to make “inspirational family programming”.
In a statement, the Sussexes said: “Our lives, both independent of each other and as a couple, have allowed us to understand the power of the human spirit, of courage, resilience and the need for connection.
“Through our work with diverse communities and their environments, to shining a light on people and causes around the world, our focus will be on creating content that informs but also gives hope.
“As new parents, making inspirational family programming is also important to us, as is powerful storytelling through a truthful and relatable lens.”