Through them, the disease had a presence in the Russian, German and Spanish royals.
But it most infamously affected Princess Alice’s Russian descendants, especially Alexei Nikolaevich.
The ill-fated Tsarevich inherited the disease via Princess Alice’s daughter Alexandra Feodorovna.
He lacked clotting protein factor IX, which resulted in several critical ruptures and led the family to seek help in peasant healer Grigori Rasputin.
